Authors: Pinto, L.S.; De Souza, M.V.N.; Kaiser, C.R.
Source: Letters in Drug Design & Discovery, v. 14, p. 678-685, 2017.
Publisher: Bentham Science Publishers
Background: In continuation of our research on sonochemistry and due to the importance and application of hydrazones and N-acylhydrazones in drug discovery, in this work we report a new general and efficient synthesis of these classes with different aromatic and heteroaromatic nucleus assisted by ultrasound and their respective anti-tuberculosis and anti-cancer activities.
Method: Derivatives 7-chloroquinoline 10 and 12 were the most promising compounds against cancer and TB, respectively. Conclusion: Unfortunately all new hydrazones and N-acylhydrazones evaluated displayed no activity anti cancer and TB.
Keywords: Hydrazones, N-acylhydrazones, sonochemistry, anti-tuberculosis and anti-cancer activities, drug discovery.
Document Type: Research Article
Publication date: 1 de Junho de 2017