Synthesis and antitubercular evaluation of aryl substituted - 2 - oxazolines from L - amino acids

Abstract

This paper describes the synthesis and the in vitro antibacterial activity of a series of twelve substituted aryl-2-oxazolines against Mycobacterium tuberculosis. Seven compounds showed activity and two compounds exhibited a minimal inhibitory concentration (MIC) of 25 g/mL were not cytotoxic for the host cells in cell viability assay. These results could be a good starting point for the development of new antitubercular lead series based on this family of compounds.

Keywords: 2-oxazolines, tuberculosis, antimycobacterial activity, L-amino acids.

Document Type: Research Article

DOI: http://dx.doi.org/10.13171/mjc.2.5.2014.06.01.23

Publication date: 1 de Janeiro de 2014

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