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[:pb]Simple and Efficient Eco-Friendly Multigram Procedure for Preparation of Piperazine Hydrochloride, an Important Building Block in Medicinal Chemistry[:]

[:pb]Authors: Costa, C.F. ; De Souza, M. V. N. ; Facchinetti, V. ; Gomes, C. R. B. Source: General Chemistry, v. 7, p. 210004, 2021 Publisher: General Chemistry Abstract This work describes the synthesis of piperazine hydrochloride in multigram scale and high yields with promising industrial applications. This methodology is simple, fast, safe, low cost, […]

[:pb]Antibacterial activity of new substituted 4-N-alkylated-2-trifluoromethyl-quinoline analogues against sensitive and resistant Mycobacterium tuberculosis strains[:]

[:pb]Authors: Da Silva, E. T. ; De Andrade, G. F. ; Araújo, A. S. ; Lourenço, M. C. S. ; De Souza, M. V. N. Source: European Journal of Pharmaceutical Sciences, v. 157, p. 105596, 2021. Publisher: ScienceDirect Abstract Objectives: The emergence of resistant strain has aggravated the tuberculosis situation in the world, running out […]

[:pb]Crystal structure, Hirshfeld surface analysis and PIXEL calculations of the three isomeric (E)-2-((pyridinylmethylidene)hydrazinyl)benzo[d]thiazoles: Occurrence of stacking interactions[:]

[:pb]Authors: Gomes, L. R. ; Low, J. N. ; Pinheiro, A. C. ; D Souza, M. V.N. ; Wardell, J. L. Source: Journal of Molecular Structure, v. 1230, p. 129907, 2021 Publisher: ScienceDirect Abstract Detailed structural analyses, utilizing crystal structure determinations, Hirshfeld surface analysis and PIXEL calculations have been carried out on the three isomeric (E)-2-((pyridin-X-ylmethylidene)hydrazinyl) benzo[d]thiazoles: […]

[:pb]Synthesis and Cytotoxic Activity of Arenecarbaldehyde 2-Pyridinylhydrazone Derivatives[:]

[:pb]Authors: Pinheiro. A. C.; Maranhão, S. S.; Carvalho, G. C.; Oliveira, A. C. A.; Pessoa, C. Nogueira, T. C. M.; Da Costa, C. F.; De Souza, M. V. N. Source: Medicine Research, v. 4, p. 200016-200016, 2020 Publisher: Medicine Research Abstract Fourteen arenecarbaldehyde 2-pyridinylhydrazone derivatives have been synthesized and evaluated,for their cytotoxic potential against four […]